Dry Fast Journal

20130319-180600.jpgToday I started on my dry fasting exeriment. My aim is to go 240 hours, or 10 days, without food or water. I should reach a state of ketosis in about 2 days, and with any luck I’ll starve my little mutants to death. My body may also look upon the 1.5-2kg of cancer cells as the ideal source of fuel and start digesting them. (I still can’t believe that I am doing this btw.)

Day 0

Starting Weight: 65.2kg
Blood Pressure: 141/96
Heart Rate: 89

3:09 – Its been just three hours and I am already thirsty. This does not bode well.

Day 1

Weight: 63.3kg
Blood Pressure: 148/97
Heart Rate: 74

So far so good. Feeling a little thirsty, somewhat hungry, but nothing I can’t cope with. Overall feeling quite well. Lost a fair bit of weight already, which I assume is mostly due to fluid loss. One advantage is not having to prepare food and I thus find myself with a lot of extra time.

Day 2

Weight: 61.5kg
Blood Pressure: 158/92
Heart Rate: 61

Surprisingly no extreme feelings of hunger or thirst. My BP is up, but this is most likely due to the fact that I am on medication for hypertension and have not taken it last 2 days. I definitely have less energy, but overall am feeling good. I had virtually no nausea for the last two days, which is another bonus. I am a little concerned with the rapid weight loss however. I have hoped to not fall below 58kg and at this rate that may not be possible.

The second half of the day hit me like a ton of bricks. I lost most of my energy and spent the rest of the day in bed. My glucose stores are depleted it seems and I should be going into ketosis soon.

Day 3

Weight: 59.9 kg
Blood Pressure: 132/93
Heart Rate: 77

I woke up feeling quite well. I have much more energy than the day before, so I assume that my metabolism has switched to burning ketone bodies now. My blood pressure has stabilized, and my heart rate is fine. Heart rate is the one to watch as this will rapidly increase with the level of dehydration.

Again no sign of my otherwise ever present nausea. I feel a little hungry, my mouth is starting to get dry, but I am not experiencing any major impulses to eat or drink. Visualising eating three meals a day and going through the motions of swallowing, seems to be helping.

I am noticing a few changes. Firstly the quality of my skin has improved. I had a problem with acne on my back courtesy of chemo. These are healing very quickly now and no new ones are appearing. Secondly when ever I took a very deep breath or pushed on my liver I felt a dull pain at my tumour sites. I don’t feel this anymore. Whether this is a good, or a bad sign, I don’t know.

My major concern is the continuing rapid weight loss. Another 1.6kg down. I am hoping it will settle down now, as there is not much more water that I can lose and I should not be burning more than 0.5kg of fat and muscle per day.

Day 4

Weight: 58.9 kg
Blood Pressure: 137/95
Heart Rate: 73

I have almost ended day four and about to start on day five. According to wikipeadia one can survive 3-5 days without water. This means that I should be dead or dying right about now. Well I hate to contradict the wikipeadia authors, but I am not dead and I don’t really feel like I am dying either.

I feel reasonably well, and had no nausea again for most of the day. It came back in the evening, but it was very mild compared to my usual.

I noticed that my feet are cold most of the time now and the only way to warm them up is to soak them in hot water. I guess that means that the dehydration has reduced the blood volume and the body is pulling blood away from the extremities in order to better protect vital organs.

I had some mild abdominal cramps in the morning for the first time too.

I spent over half the day in bed and I am having trouble sleeping. I slept for only 4 hours. My qigong master did however mention that during the fast I will require less sleep. I guess he was right.

It is surprisingly easy to stick to the fast, even though I am surrounded by family going through their regular routine of 3 meals a day with snacks in between. I expected the fast to be much harder.

Looking in the mirror, I don’t look great. I lost a lot of weight now and my face looks rather sunken. The weight loss concerns me the most. It looks like my body started to burn muscle tissue even though I still have some fat reserves left. Not overly happy about this as it took 5 months of hard work in the gym to regain my muscles after my spell of cachexia 5 months ago. I was hoping to not fall below 58kg, but this does not appear likely. My absolute minimum for my height is 55kg. I am happy to continue up to that point, but not lower. This gives me about a 4 kg reserve left.

Day 5

Weight: 58.1 kg
Blood Pressure: 128/79
Heart Rate: 62

This has been the worst day so far and I was seriously thinking about stopping at this point. I had very little energy, was feeling very tired and spent most of the afternoon in bed not being able to do anything. (I should probably clarify that I started fasting at 3pm, so my fasting days are 3pm to 3pm the following day.)

I had a strange chemical taste in my mouth for several hours in the evening. I believe that this is due to the chemo drugs that accumulated in my fat tissue, which now being burned, is releasing these toxins. I also felt a mild nausea in the evening.

I decided to continue with my fast as my brain is still sharp. Master Tao mentioned that I should stop the fast once my mind starts to become dull. If anything my mind was working overtime and I had to meditate before sleep as had no hope of actually going to sleep otherwise. Even the meditation proved hard and took an hour to finally settle my mind

In the morning I woke refreshed and I am once again feeling quite well, so will be continuing.

A new symptom has surfaced. I now get short dull pains in my liver from time to time. These usually last a second or two then stop. I assume this means that something is happening. Hopefully my little mutants are having a hard time and are dying.

I decided to continue my Iscador injections during my fast. I am still on low dose and I have not had a reaction to the injections prior to my fast. During the fast however, I noticed that the injection sites are sore for several days afterward and the skin around them are a little red. This shows an immune reaction taking place. It looks like my immune system is indeed stronger when the body does not need to spend energy on digestion. Hopefully another good sign.

I lost the least amount of weight so hopefully my weight loss is slowing now. Blood pressure is dropping due to dehydration. Heart rate is still good however.

Day 6

Weight: 57.7
Blood Pressure: 141/86
Heart Rate: 61

Pretty much same as yesterday. Feeling relatively ok till about mid afternoon, then seem to run out of energy and feel very tired for the rest of the day.

Blood pressure increased, which was unexpected, heart rate still fine and lost only 0.4kg since yesterday. It looks like I am not losing as much fluids now, which would account for the relatively minor weight loss.

Delirium has not set in yet (as far as I know), so I will continue. Just 4 more days to go.

Day 7

Weight: 57.0 kg
Blood Pressure: 118/89
Heart Rate: 67

I did some gardening, which probably explains the greater weight loss today, but I felt like I had the energy today and it needed doing. However as before, my energy evaporated by early afternoon and I felt weak and tired the rest of the day.

My blood pressure is now quite low compared to my usual. This is a typical body response to dehydration, but my heart rate is still normal.

I took my body temperature and it is running lower than normal at 36.3 degrees Celsius. It should be at or slightly above 36.6. I suspect that this is another way that the body deals with starvation. The reduced core temperature means the body needs to burn less energy. I took a long warm bath to get it up and to warm my ever cold legs. I am not sure if this was a good idea as I read in one article that the skin can absorb 18g of water per hour through osmosis. In another article it however mentioned that only the upper layer of the skin absorbs water and it does not get into the body. This is the reason why your skin goes wrinkly in water, and returns back to normal after the extra water evaporates. Either way, I think 50ml of water should not make a difference, even if it was absorbed.

The strange chemical taste in my mouth continues and has increased in the evening to a point where I started to feel sick from it. It feels like its 5-FU as I recall similar taste on both folfix or folfiri i think, however oxaliplatin makes more sense as this accumulates in fat tissue and can linger in the body for many years. I started to rinse my mouth with water and spit out the saliva. This helped a great deal. I probably ingested some water by doing this, but I figure that I spat out just as much saliva to compensate.

I expected my level of urination to be greatly reduced by now, but this does not appear to be the case. My urine us quite yellow, which is still ok. If it turns brown, this would be a cause for concern as at that point kidney damage becomes a real possibility.

Standing up I am now noticing pins and needles in my feet, much like the oxaliplatin induced neuropathy, however nothing in my fingers, so I don’t think its due to oxaliplatin. Probably just another side effect of dehydration and the reduced circulation in the extremities. I also feel quite dizzy for a few moments and I stumble a bit just after standing up. This I am sure is due to the low blood pressure.

I am still feeling fine, no sign of elevated heart rate or delirium, so I am continuing. Just 3 days to go now.

Day 8

Weight: 56.8 kg
Blood Pressure: 129/80
Heart Rate: 62

Woke up feeling quite well again. Core temperature still at 36.3 in the morning and lost only 200g of weight. (I may turn into a breatharian at this rate 🙂 ). Both blood pressure and heart rate good.

In the late afternoon I felt like I lost all of my energy. Was feeling weak and tired. This was the worse I have felt energy wise since starting. An unexpected development was a low grade fever in the evening of 37.7 Celsius. I am not sure what caused this. Could have been the GCMAF injection I had today or yesterday’s Iscadore (mistletoe), but these never caused a fever before. Secretly hoping that the elevated temperature is due to cancer cell die off. After all this is why I am doing this.

My mouth is becoming very dry. I still have some saliva, but its much more viscous. There is just enough to keep my mouth somewhat moist, but not enough to swallow. My voice has also changed significantly. This will be due to the drying out of the vocal chords I expect.

Still have the strong chemical taste in my mouth, but only in the late afternoon and evening.

Into the final stretch, just 2 more days to go.

Day 9

Weight: 56.3 kg
Blood Pressure: 120/84
Heart Rate: 70

Day nine is the day my saliva ran out. Its a very weird feeling having a totally dry mouth. I am coping by rinsing my mouth out with water every so often. That helps a lot and makes it bearable. I have also noticed that my skin is now quite dry.

Lost another 500g, blood pressure is low for me but the heart rate is still good. I will thus continue for another day.

I still have good energy levels in the morning, but feel extremely weak and tired from mid afternoon.

I saw my Qigong master. He said that I still look quite good and suggested that I should fast an extra three days. I politely told him what he can do with that idea. I have a chilled fresh coconut in the fridge with my name on it, and I am sooooo looking forward to it. This will be my first drink in 10 days and I am not waiting another 3 days. The reason I picked a fresh coconut to start with is because the coconut milk is full of electrolytes.

My local reactions to Iscador are getting stronger, now leaving a sore, hard and swollen lump at the injection site. Looks like my immune system is getting better with each day on the fast. Whether the fast has any impact on my cancer still remains to be seen.

Just one more day to go.

Day 10

Weight: 56.0 kg
Blood Pressure: 116/82
Heart Rate: 86

WOW I made it. Day ten is almost over and I must say that it was the hardest day to date. Had this not been the last, I most likely would have quit at this point.

I went shopping today in order to buy all the food I was going to eat over the long easter weekend coming up. It was hard and was at times glad to have the support of the shopping cart as was not all that stable on my feet. I bought mostly fruit and a few vegetables. Not sure why but I have this great urge to eat fruit. I guess its because it is full of sugars and carbs, something that my body desperately needs the most at this point.

The reason I mentioned that I would have stopped after this day is my mind started to get fuzzy. I found it hard to think, hard to concentrate and made a few rather obvious mistakes during the day by not being able to think things through.

Had my first bowel movement today since day 1. Not overly pleasant. The odor very similar to the nasty chemical taste that I had in my mouth. I guess the detox part of the fast is working.

Had some liver pains today and a dull pain at the site if the primary tumour. This is the first time i experienced it at this level since starting. I am in two minds about that. Could mean that things are happening and the extra three days I was recommended to do, could possibly have a major impact. But based on my physical health, not a good idea and decided against it.

Was feeling hungry today. Hunger I have not really felt for over a week now. I assume its the anticipation of breaking the fast.

Sleep was again an issue. The past week I tend to wake up at 4 am. Seems like that while fasting I only need 4-5 hours of sleep.

I lost a total of 9.2 kg over the past 10 days. It was a challenge I set myself, one that I never believed that I would complete. I don’t know if this fast will do anything for my cancer, but hopefully there will be some visible changes on my bloodwork due on the 4th of April. I will post my results.

As a warning, this was my personal experiment and I do not endorse or recommend it to anyone else. Please note that there are many documented cases of people dying after 5-7 days of dry fasting.

Now to break open that young coconut I have been soooo looking forward to.

Resources

Fasting
Bigu

Posted in My Journey, Treatments | 9 Comments

Dry Fast Aftermath

For those of you following my blog, you will know that I had recently completed a 10 day dry fast. That’s 10 days without food or water. The aim was to try and make life as difficult as possible for my cancer cells. This post is about the first few days after my fast, which in many ways proved more challenging than the dry fast itself.

Day 1

My plan was to take it easy and have a young coconut, glass of water and a banana the first day after my 10 day dry fast. Well this proved much harder than sticking to the fast and I failed miserably. I ate more fruit than I had in mind, not having the willpower to stop. Needless to say I paid the price. I got quite sick, and my heart more than doubled to over 200 bpm for an hour or so. I recovered in a few hours, and was able to eat after that having a light dinner in the evening.

Day 2

When I woke up, all hell broke lose. My liver swelled up and I had severe liver pains for most of the day. My usual nausea also made a comeback. At this point I don’t know if this is a good or a bad sign.

Day 3

My liver is still very swolen. Liver pains continue, though not as severe as the day before. Feeling very tired.

Day 4

Liver still swollen, liver pains continue. Nausea getting worse in the evenings. Feeling very tired from noon onwards.

Day 5

Liver still swollen, still have some liver pains, however not as bad now. Less nausea.
Recovered a little over 4 kg of weight. Now 61.4 kg. Assume its mostly due to rehydration. Not feeling as tired as last few days.

Day 6

Had a high dose vitamin C IV today (90g). Within 30 minutes all liver pains were gone. By the end of the day no more liver swelling. Nausea much better. Interesting side effect of vitamin C. Will file away for future reference. Quite a strong reaction to my iscador injection. Very swollen and painful.

Day 7

Start ing to feel good. No liver swelling, no pain, no nausea. Saw my qigong master today to consult the progress of the fast. His reaction was that I look quite good. Well I feel good. Master said that all my organs are fine. He still feels problems with my liver, but says that it is much better now. He recommended that I delay my next chemo, and do 7 more days of dry fasting. I will consider that if my blood tests show an improvement. Had my blood tests done today.

Day 8

Feel better than I had in months. I look better as well as commented on by several people. Virtually no nausea for last 3 days which is new for me and hopefully a good sign. Got my blood test results today. Results were quite Disappointing to say the least and do not reflect the way I feel. Liver function only marginally better, CEA rose again reaching almost the 3000 mark. One surprise is that my Monocyte and Eisinophil counts are more than double compared to the last tests, but I suspect that these are due to the strong Iscador reaction. Also unusual, my bicarbonate levels are in the normal range for the first time in 6 months.

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Last Chemo

20130408-140728.jpgFor better or for worse, I have decided to stop systemic chemotherapy and last friday was my last cycle.

I have known since day one that chemo was a dead end. For the majority of cancer patients, chemo does not lead to a cure. Chemo destroys everything including healthy cells and wrecks havoc with the immune system. I am no longer prepared to do that to myself.

My decision is also in part due to the fact that neither the first line folfox, or second line folfiri chemotherapies worked well enough to reduce my tumour load. Officially I have achieved stable disease for the last 6 months, however most of my liver mets grew by a few millimetres. Its not even certain whether chemo had anything to do with this slowdown in growth.

I realise that I am taking a huge risk in light of my extensive liver mets, but I have to try something different. I believe that the only path to a potential cure lies with my immune system, and that is the path I have decided to follow.

Next week I am off to Germany to explore a range of alternate and off-label therapies. Its expensive as heath insurance will not cover it, however many of these treatments are simply not available in Australia.

My Germany based treatment plan includes:

Chemoembolization of the Liver
Dendritic Cell Therapy
NDV oncovirus
Removab antibody for my epCAM positive cancer
Hyperthermia
Thyroid based therapy

Posted in My Journey | 2 Comments

One Night in Bangkok

20130417-074935.jpgOk, well actually two nights. Still way too short, but time is of the essence since stopping systemic chemotherapy. I am on my way to Europe for some cutting edge cancer treatments mostly in Germany and after my last flight experience, breaking up the trip with a stop over in Bangkok seemed like a good idea.

I still have bad memories of my last intercontinental flight seven months ago, returning from a US business trip. It was a long and complicated flight, LA-Tokyo-Bangkok-Singapore-Melbourne.

This was just before I knew that I had stage 4 colorectal cancer, but I was already suffering from liver failure and feeling very ill. During the third leg of my flight from Bangkok to Singapore things got so bad I could hardly walk off the plane and ended up crashing at an airport hotel in Singapore. Six hours spent mostly on the shower floor combined with a pack of motion sickness tabs bought at the airport pharmacy allowed me to recover enough to continue. Still, it was an absolute horror flight. At that time I believed I caught some gastro bug or stomach flu. (I wish)

My current trip to Germany started off badly. I felt very sick in the morning of the flight and nausea made a comeback for the first time since my fast. Maybe the stress, the running around, last minute packing etc. The memories of my last flight replayed in my head, but it was too late to turn back now. I took some steroids, the first anti nausea medication I have taken in five months, but this did nothing. In the afternoon, two hours into the flight, the nausea finally passed and I was even able to stomach the airline food. I breathed a sigh of relief and landed in Bangkok feeling well.

Thailand is great and although I am just staying at the airport hotel, I wish I could stay longer. Luckily my nausea did not return and I had fabulous two days. Gym, qigong, meditation a massage at the hotel spa and of course great thai food I love so much were on the daily menu. Overall a very relaxing two days. (I so needed this.) I fly out later today and as soon as I land in Europe, the serious work begins. My first treatment starts in Prague, 2 hours after I get off the plane, then off to Germany a week later. Like I said, no time to waste.

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IV Ozone Therapy

20130419-141540.jpgToday I visited a clinic in Prague where I was introduced to IV based ozone therapy. In a nutshell, a solution is saturated with ozone and this is then infused over about 15 minutes. After some further research I agreed and had my first ozone IV.

In vitro, ozone itself has been shown to be very effective in killing cancer cells. Unfortunately this does not translate in vivo as the ozone oxidises well before it is able to reach the tumour sites. This is because Ozone will last only about 20 seconds in blood plasma. It however has other potential benefits.

The theory behind this therapy is to induce mild oxidative stress. The word mild is important because ozone is a powerful oxidant and is toxic in higher doses.

Ozone Therapy Benefits

Ozone oxidises various chemicals in blood plasma, the peroxidation products of which have potential therapeutic properties.

The ozone induced oxidative stress has been shown to mildly stimulate the immune system by activating T Cells.

Ozone therapy increases glycolytic enzymes and this enhances glucose metabolism, increasing the biosynthesis of NO and CO. This stimulates blood flow and oxygen delivery into hypoxic tissues. Tumours thrive in hypoxic (low oxygen) environments so this may provide an additional therapeutic effect.

Ozone therapy has not been shown to be a cure for cancer, however there are older studies suggesting increased survival times.

Ozone therapy has demonstrated an ability to improve the life quality of cancer sufferers.

My Experience

The Ozone IV solution has to be prepared on the spot using a special ozone generator. It was infused via a slow drip over a 15 minute period. I have noticed no side effects following the IV. This was to be expected as in general Ozone therapy is well tolerated.

I intend to return to the Prague Clinic after my german treatments and pursue the Ozone therapy over a 2 month period as I believe a sustained treatment is needed to be able to demonstrate clear benefits or the lack of.

Resources

Mechanisms of Action Involved in Ozone Therapy

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Iscador (Mistletoe Extract)

20130424-140524.jpg

I have been taking mistletoe injections for over 2 months. One injection every 2 days. Specifically I am taking Iscador QU and about to start on series 2.

The doses start with series zero, which is a low starting dose. The dosing depends on the local immune reaction. The expected reaction is redness, swelling, itching. I also had a hard lump develop around the injection area with lots of pain. Once the body develops a tolerance to the mistletoe antigens, the dose is increased. There are 4 series and each series has stronger concentrations. Once series 3 stops evoking a local response, a different type of mistletoe is used.

The theory behind mistletoe is to stimulate the immune system. The hope is that just like with Coley’s toxin, the immune reaction it causes, will in some patients at least, translate to the cancer cells. I am not sure that I believe this claim however (taken from the manufacturer’s site). You can multiply the various white blood cells as much as you like, but if they do not recognize the cancer cells, it will make no difference. Still during chemotherapy at least, stimulating the immune system is a good thing in my view, even though it may have no impact on cancer cells.

I had very mild local reactions to Iscador, up until my dry fast. About half way into the fast, the local reactions increased dramatically. Lot of swelling, redness and the injection sites developed hard lumps that were extremely painful to the touch. This reactions lasted for about ten days after the fast, then virtually disappeared with new Iscador injections causing virtually no localised immune response since. The reaction during and following my fast were reflected in my blood test. My Neutrophil and eisinophil counts more than doubled. It would appear that as predicted, the immune system is much stronger during fasting when the body is not burdened with digestion, which is a very energy intensive process. I am now seriously considering repeating the fast just after I receive my first dendritic cell vaccine in a couple of weeks from now, to ensure that my immune system is as strong as possible.

About 1000 in vitro studies have shown that mistletoe or its main constituents (alkaloids, lectins, and viscotoxins) do have anticancer activity, however many plants have some sort of anticancer activity, so this in itself is not unusual.

In Australia, Iscador can be ordered from New Zealand. In the US, the FDA has not approved mistletoe as a treatment for cancer or any other medical condition and does not allow injectable mistletoe to be imported, sold, or used except for clinical research.

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Jurkovic Protocol

20130426-131317.jpgWhen I began my search for a potential cancer cure, one of the “off the beaten track” treatments caught my attention. It was a treatment developed by DR. Jurkovic, and involved manipulating the thyroid in order to disrupt the cancer’s metabolism. It also include immunoglobulin to stimulate the immune system and two enzymes, trypsin and chemotrypsin to disrupt the tumor integrity so that the immune system can get inside tumours.

I already wrote an artice on DR. Jurkovic and his protocol, and the full story can be found here:
http://www.mcrc4.com/?p=1813

Dr. Jurkovic treated hundreds of cancer patients and kept detailed records. His published case studies and results seem to greatly outperform the best available chemotherapy treatments. I went a step further and contacted some of his former patients. I found and spoke with two terminal cancer patients that dr. Jurkovic treated. They are now 12 and 14 years after treatment and both are cancer free. I don’t know of any traditional oncologist who can make the same claim. One patient had Pancreatic cancer and to my delight, the other had Colorectal. One of these patients put me in touch with a doctor that continues to treat patients using the Jurkovic protocols. Last week I visited a clinic in Prague and started treatment.

The Jurkovic treatment is quite simple. Firstly I take Thyrozol twice daily. This is a standard drug used to treat hyperthyroidism. The aim is to retard the function of the thyroid gland and thus mess with the body’s metabolism.

Secondly I take pure trypsin and chemotrypsin. This is applied rectally in a 10ml saline solution. The application method, I was told is essential, as if taken orally, the digestive system destroys most of the enzymes. Also when applied rectally the enzymes go directly into the liver, which in my case is exactly where I need them to be. These enzymes can also be injected into the tumour directly, or into the perionteal space to treat ascites.

Immunoglobilin injections are also given every second week. These are given into muscle and hurt like hell. Had my first, and the second I am to apply myself. Ouch.

Lastly cimetidine was also prescribed.

In addition to these, the clinic where I am getting treatment offers a range of adjuvant therapies. I am getting, Ozone, Bicarbonate and High dose vitamin C as an IV and a range mushroom extracts that the clinic supplies in ultrafiltered solutions placed under the tongue for maximum bioavailability.

So far I have noticed no side effects related to the treatment. I did however have a lot of pain and my liver swelled up about a week after starting treatment. This went away the following day, but I can not say whether that was as a result of the Jurkovic treatment. The other major benefit is that the treatment is very affordable. If a doctor is willing to prescribe the medication, it can also be done anywhere.

Using the thyroid to treat cancer is not as far fetched as it seems. There is some cutting edge research that has concluded that manipulating the thyroid hormone levels is potentialy a novel approach for treating cancer. A lot of the thyroid research seems to be coming out of Israel. (You can pubmed it.)

Its also worth mentioning that trypsin and chemotrypsin are commonly used in the treatment of cancer in veterinary science. Seems like you have a much better chance of beating cancer if you are an animal. Go figure.

I was told that I need to follow the treatment for a minimum of three months to see the benefits. I will report on the results, but I have a good feeling about it and will continue to travel from Germany to visit the Prague clinic at least once a month.

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Coffee in Duderstadt

20130426-140114.jpgI arrived in Duderstadt today to begin dendritic cell immunotherapy. I drove 5 hours from Prague and just made it in time for the initial meeting with Dr. Nesselhut and to have some initial blood tests done in preparation for Leukapheresis.

Leukapheresis involves being hooked up to a special machine that extracts blood from one arm, spins the blood to separate the various plasma components, extracts the white blood cells and returns the rest via the other arm.

Anyone who has been reading my blog probably knows about my feelings toward needles. I know its psychological, I know I should be used to it by now, but I still get sick when anyone tries to take blood from my veins, or worse. The chemo port is another matter. I have even accessed the port using the gripper needle myself, and I am totally fine with this. I don’t quite understand it.

Anyway, I was told that the port can not be used so had to have 2 cannulas put in. First one was not too bad, I got some hot flushes, but that was about all. The second arm proved to be somewhat more problematic. After several goes at trying to insert the cannula into various veins, they eventually gave up and decided to use the port after all. I was feeling quite ill by that stage, but I am making progress. Few months ago after multiple cannula insertion attempts like this I am sure that I would have passed out.

I spent about 2 hours hooked up to a dialysis style machine and I now have enough blood cells stored to produce enough dendritic vaccine to last months or even years. The frozen cells will be thawed as needed and grown in the lab to mass produce dendritic cells. The dendritic cells will then be activated by exposing them to antigens. The theory is that once re-introduced into the body, they will help to activate the immune system in a way that it recognizes the cancer cells. Unfortunately the response rate to this therapy is only 30%, however I have been told that the percentages do improve when combined with other therapies. One of these is the Removab triclonal antibody. This antibody attaches to epCAM positive cancer cells, tags the cells and exposes them to the immune system. Removab is used off label at Hallwang and as consequence, it will be the next stop on my cancer clinic world tour.

Following the Leukapheresis Procedure I felt very tired. I did plan to drive to Hallwang straight after, but decided to stay another day in Duderstadt. I did not think that a 6 hour drive would have been a good idea in my current state and Duderstadt is such a nice city anyway.

If the Dendritic vaccine does not work, plan B is the Newcastle Disease oncovirus. The virus attacks cancer cells leaving normal cells unharmed. The infected cancer cells are altered and become exposed to the immune system. Failing that, Plan C involves gamma-delta cells.

Posted in Gamma-Delta T-Cells, My Journey, Treatments | 1 Comment

Hallwang Blues

20130507-163502.jpgI arrived at Hallwangen on Saturday, and stayed two days at the BelVital hotel. Nice place overall but the claustrophobic bathrooms took a bit of getting used to. On Sunday I drove to the Hallwang Clinic to check the place out. From the outside, it looked like a nice place nestled on a hill in a small german town. I’ll be moving into the clinic on Monday and I expect to be spending a lot of time here over the coming months.

Hallwang proved to be quite a depressing place initially. Its a clinic that also treats terminal cancer patients, those that traditional medicine had given up on and were sent home or to a hospice to die. Emotionally I found it quite distressing, seeing people unable to walk or even feed themselves. This is not something you get to see in typical chemo infusion wards. I always try to be positive, but I could not help thinking that this could be me in a few months. After a few days I came to terms with it and am back to my optimistic self. I guess meeting Pete and Tedd in person whom I only had known through skype and forums had a lot to do with it. In many ways kindred spirits willing to also go down the road less travelled.

As soon as I got in, I had an initial consultation with the hallwang doctors, and was started on some IV drips. I was also booked in for Chemoembolization with Prof. Vogl the following day. Great, I had only just arrived and was being shipped off to Frankfurt. Everything seems to be done very quickly here. Hyperthermia the day after and the big one, Removab at the end of the week. Then another six hour drive to Duderstadt for my first dendritic cell vaccine. I may also drive back to the Prague clinic for a week, before returning to Hallwang. I am however very tempted to stop all treatment after the vaccine and go on another 10 day dry fast. My immune system went into overdrive last time, and this could be just what the dendritic vaccine needs.

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To Hell And Back

20130501-175216.jpgShortly after breakfast, I left the Hallwang clinic for Frankfurt. It was a three hour drive, and I was going for an appointment with Prof. Vogl to have my first chemoembolization. I spoke to the hallwang doctor, and patients who had the procedure already and all painted a very rosy picture of a simple and painless procedure. I was assured that I would be fine to drive back afterward. Seems I am again the exception rather than the rule.

The Germans are very efficient, I give them that. 5 minutes after I arrived I was prepped for the procedure and 20 minutes later I was getting an MRI. After the MRI I was taken into the theatre where the chemoembolization was to take place.

The procedure started with local anaesthetic to the groin area. Then far too quickly, the obviously very busy and impatient prof. Vogl made a small incision to expose the femoral artery… before the anaesthetic had a chance to work. But no great drama.

Next the catheter was inserted into the artery and slowly threaded all the way up into the liver. Quite interesting to see the procedure on the computer screens. Once in place, the chemotherapy agents were injected, followed by an injection of embolization agents to seal off the hepatic artery to ensure that the chemo stayed inside the liver. Overall the entire procedure took maybe 15 minutes. (This is important, if getting chemoembolization done elsewhere, ensure that the embolization is temporary. Some older procedures block the veins permanently and you do not want that.)

5 minutes after the chemicals went in, things started to get bad and I started to feel pain in my liver. Ok, the liver feels no pain, as it has no pain receptors, but the sack enclosing the organs does. 10 minutes later the pain was excruciating. In fact I have never felt pain like this. I have had some very extreme liver pains in the past, but this was at least double in intensity. I was shaking, sweating profusely, my blood pressure jumped to over 200 and I was clutching the bed rails in agony. If I had a choice of a quick death at that time I would have been very tempted to take it.

It reminded me of my daughter. When she was about 3 years old she touched a hot light globe and burn’t herself quite badly. At first she would say nothing and did not cry. She was very brave probably not wanting us to find out what happened. But she was acting oddly, and when we asked what was wrong she told us and finally broke down. She would whimper ‘It hurts, It Hurts, It Hurts….’ but in Czech: ‘To boli, To boli, To boli, …’ It broke my heart to hear her. I found myself shaking, soaked in sweat, gripping the bed rails whimpering just like her ‘To boli, To boli, To boli,….’. Must have been quite a sight for the nurses, though I guess they just attributed my ramblings to the morphine.

Yes, they pumped me full of morphine, but all that did was to take the edge off a little, but overall not a great difference. Next was a CT scan. Trying to get on the CT machine in my current state was another experience and took a lot of will power.

After the CT, I spent three more hours in the recovery room in agony, before the pain subsided enough to be at least tolerable. I was then taken for another CT scan and discharged. At this point I started to regret driving myself to Frankfurt (to save 500 euro), as I now had to drive 3 hours back to Hallwang. I was considering finding a hotel in Frankfurt, but rather than dealing with this I just decided to grind my teeth and drive back to Hallwang. (How did I get discharged you ask? Well I kinda lied a little about how I really felt.)

I don’t know what the pain meant, but I had a look at the two CT scans taken just 3 hours apart. The difference was amazing. White rings surrounded most of my liver mets, which I was told was a physiological reaction to the chemo. In other words, visible cell death just three hours after the procedure. I had more tumour shrinkage in 3 hours than I had in 6 months of systemic chemo. That’s encouraging and almost worth the ordeal. 🙂 Another good news is I am not experiencing any of the typical chemo side effects like oxaliplatin neuropathy, nausea etc., even though the doses used were many times higher than would be possible with systemic chemotherapy.

Since I am writing this, I guess I made it to Hallwang, though I am not sure how. I got in at about 9pm, but it did not end there. I spent most of the night curled into a foetal position on the shower floor. The hot water providing a little relief. (I felt a little guilty for using up so much water, but there was no bath tub.) The pain was still bad and I simply could not sleep. It was not till about 7am that the pain started to pass. By noon I was back to normal and they hooked me up to more IVs. Just like any other day.

I can now truly say that I have been to hell and back and after this, I am ready for just about anything. Unfortunately I am booked in for another chemoembolization session 3 weeks from now, and I am not sure whether I am ready to go through that again. But I guess I have no choice.

The aim of the inital chemoembolization is to break down the tumour structures as much as possible so that the Removab antibodies can reach and tag the epCam positive cancer cells which then the immune system attacks and destroys. To help this process, billions of cultured white cells I will also have injected at another clinic. Removab will go in within the next 3 days. Unlike chemoembolization, most patients that had Removab report severe side effects lasting several days. God help me.

Posted in Chemoembolization, My Journey, Treatments | 6 Comments