Tetrathiomolybdate

Posted on March 15, 2013 by Ren

20130315-125508.jpgIt took a while, but my Tetrathiomolybdate order arrived today. TTM is a powerful copper chelator and because I have high copper levels and the fact that copper is crucial to angiogenesis, its time to get as much copper out of my body.

Tetrathiomolybdate (TTM) was developed as an effective anticopper therapy for the treatment of Wilson’s disease, a disorder that leads to abnormal copper accumulation. As copper plays an important role in angiogenesis it is speculated that copper depletion can lead to stable disease in metastatic cancer. This outcome has in fact been observed in several clinical studies.

Resources

  1. Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Antiangiogenic Agent: Phase I Study
  2. Phase II Study of Tetrathiomolybdate (TM) in Patients With Breast Cancer
  3. The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies
  4. A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer.

About Ren

I have been diagnosed with stage 4, metastatic colorectal cancer in October 2012, 3 days after my 44th birthday. There is no cure, but I am determined to go down the road less travelled to find one. I have setup this blog to document my journey and hopefully help others in the process. My view is that if there is a cure, it does not lie with traditional chemo, but with the immune system. Time will tell.
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